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Dr. Mario Rossi

mrossi@ibioba-mpsp-conicet.gov.ar

Graduado en Ciencias Biológicas en la Universidad de Buenos Aires, Argentina. Doctorado en la Universidad de Roma "Tor Vergata", Italia. Estudios Postdoctorales en la Unidad de Toxicología del Consejo de Investigación Médica (MRC), Leicester, Reino Unido y en el Centro Médico de la Universidad de New York, USA. A partir del 1 de marzo de 2012, Investigador de CONICET a cargo del grupo de investigación "Autofagia y Sistema Ubiquitina/Proteosoma" en el IBioBA-MPSP.

Publicaciones destacadas


Rossi M, Rotblat B, Ansell K, Amelio I, Caraglia M, Misso G, Bernassola F, Cavasotto CN, Knight RA, Ciechanover A, Melino G.
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs asregulators of autophagy.
Cell Death Dis 5:e1203 (2014)


Jeong, Y.T.; Rossi, M.; Cermak, L.; Guijarro, M.V.; Saraf, A.; Florens, L.; Washburn, M.P.; Sung, P.; Hernando, E.; Schildkraut, C.; Pagano, M.
FBH1 mediates DNA double strand breakage and apoptosis in response to DNA replication stress.
J of Cell Biol. 200:141-9 (2013)


Rossi, M.; Duan, S.; Jeong, Y.T.; Horn, M.; Saraf, A.; Florens, L.; Washburn, M.P.; Antebi, A.; Pagano, M.
Regulation of the CRL4Cdt2 ubiquitin ligase by the SCFFbxo11 ubiquitin ligase.
Mol Cell. 49:1159-66 (2013)


Abbas, A.; Mueller, A.; Shibata, E.; Keaton, M.; Rossi, M.; Dutta, A.
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
Mol Cell. 49:1147-58 (2013)


Duan S, Cermak L, Pagan JK, Rossi M, Martinengo C, di Celle PF, Chapuy B, Shipp M, Chiarle R, Pagano M.
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
Nature. 481:90-3 (2012)


Rossi M, Munarriz ER, Bartesaghi S, Milanese M, Dinsdale D, Guerra-Martin M, Bampton ETW, Glynn P, Bonanno G, Knight RA, Nicotera P, Melino G.
Desmethylclomipramine induces accumulation of autophagy markers by blocking autophagic flux
J Cell Sci. 122, 3330-9 (2009)


Melino G, Gallagher E, Aquileian R, Knight RA, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A, Bernassola F.
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer
Cell Death Differ. 15:1103-12 (2008)


Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G.
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
Proc Natl Acad Sci USA 104:11280-5 (2007)


Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM, Melino G.
The E3 ubiquitin ligase Itch controls the protein stability of p63
Proc Natl Acad Sci USA 103:12753-8 (2006)


Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu YC, Vousden KH, Cesareni G, Melino G.
The Ubiquitin-Protein Ligase Itch regulates p73 stability
EMBO J. 24:836-48 (2005)


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